Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22 |
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| Authors: | A P Palumbo M Boccadoro S Battaglio P Corradini B Giovinazzo G Avanzi G Ponzio |
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| Institution: | Dipartimento di Medicina e Oncologia Sperimentale, Universita' di Torino, Italy. |
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| Abstract: | We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13). |
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