老年患者股动脉和颈动脉及冠状动脉粥样硬化斑块稳定性的比较

目的　探讨股动脉、颈动脉、冠状动脉粥样硬化斑块的稳定性。方法　收集我院老年尸体解剖病例 15例 ,将所有病例的两侧股动脉、两侧颈动脉、左冠状动脉前降支进行连续取材 ,常规病理检查 ,部分节段行α 平滑肌肌动蛋白、CD6 8、bax染色。结果　股动脉粥样硬化斑块中的平滑肌细胞、巨噬细胞数量与颈动脉相近。与冠状动脉比较 ,股动脉粥样硬化斑块中的平滑肌细胞相对多 ,巨噬细胞相对少 ;bax在巨噬细胞的表达多 ,在平滑肌细胞的表达少。结论　平滑肌细胞、巨噬细胞数量的不同导致了 3种动脉粥样硬化斑块不同的稳定性。股动脉中的粥样硬化斑块较冠状动脉更稳定。

The comparison of plaque stability between femoral,carotid and coronary atherosclerosis in the elderly patients

Objective To investigate the plaque stability between femoral,carotid and coronary atherosclerosis.Methods Fifteen elderly autopsy cases were selected in our hospital. Serial sections of femoral artery, carotid artery and coronary artery of all cases were taken. All the arteries were examined.some of the segments were selected for immunohistochemical staining of three markers,i.e.α-smooth muscle actin, CD68 and bax.Results The number of smooth muscle cells and macrophages in femoral atherosclerotic plaques was similar to that in carotid atherosclerotic plaques. Compared with coronary, there were more smooth muscle cells and less macrophages in femoral atherosclerotic plaques.The expression of bax was intense in macrophages and weak in smooth muscle cells.Conclusions The different number of smooth muscle cells and macrophages leads to different plaque stability between femoral, carotid and coronary atherosclerosis.It seems that the plaques are more stable in femoral artery than in coronary artery.