老年高血压病患者血尿酸水平及其他心血管相关因素

目的 观察老年高血压病患者血尿酸,血脂,胰岛素抵抗指数和内生肌酐清除率等相关因素，探讨血尿酸在老年高血压病患者中的临床意义。方法 老年高血压病组78例（A组），中青年高血压病组57例（B组），老年健康对照组41例（C组）。测量体质量指数（BMI），腰围（WC），腰臀比（WHR），检测血尿酸（SUA），总胆固醇（TC），三酰甘油（TG），高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），空腹血糖(FBG)，空腹胰岛素水平（FIn），计算胰岛素抵抗指数（HOMA-IR），血肌酐(Scr)，计算内生肌酐清除率（Ccr）。结果 高尿酸血症发生率分别为A组:23%，B组:28%，C组:2%。A组与C组比较，A组BMI、WHR、SUA、TG、TC、SBP、DBP、FIn、HOMA-IR均明显升高，A组Ccr、HDL-C低于C组,具有统计学意义（P<0.05）； A组与B组比较，A组WHR、FIn、HOMA-IR、Ccr、DBP低于B组，具有统计学意义（P<0.05）。结论 高血压病患者高尿酸血症发生率明显升高，血尿酸可作为高血压病患者临床评估的重要指标之一。

Analysis of serum uric acid and cardiovascular risk factors in elderly patients with essential hypertension

AIM: To study serum uric acid (SUA), blood lipids, insulin resistance, and endogenous creatinine clearance in elderly hypertensive patients. METHODS: Serum uric acid and other clinical data were collected in 78 elderly hypertensive patients (group A), 57 middle-aged hypertensive patients (group B) and 41 elderly normal controls (group C). RESULTS: Hyperuricemia in groups A, B and C was 23, 28 and 2%, respectively. In group A, the BMI, waist-to-hip ratio (WHR), SUA, triglycerides, total cholesterol, systolic blood pressure (SBP), diastolic blood pressure (DBP), Fin and HOMA-IR were higher than in group C, but creatinine clearance (Ccr) and high-density lipoprotein cholesterol were lower than in group C (P<0.05). WHR, Fin, HOMA-IR, Ccr and DBP in group A were lower than in group B (P<0.05). CONCLUSION: The incidence of hyperuricemia is significantly increased in hypertensive patients. The serum uric acid is one of the important markers for clinical analysis in both elderly and middle-aged hypertensive patients.