| 挤出滚圆法制备中药复方当归补血微丸及其性质考察* |
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| 引用本文： | 陈红霞,贾晓斌,陈彦,施亚芳,孙晶. 挤出滚圆法制备中药复方当归补血微丸及其性质考察*[J]. 中国新药杂志, 2007, 16(8): 625-628 |
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| 作者姓名： | 陈红霞 贾晓斌 陈彦 施亚芳 孙晶 |
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| 作者单位： | 1. 江苏大学药学院,镇江,212001
2. 江苏省中医药研究院,南京,210028 |
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| 摘 要： | 目的：应用挤出滚圆法制备中药复方当归补血微丸，研究微丸制备的最佳工艺和处方。方法：用新型的挤出滚圆造粒机制备当归补血微丸；采用单因素考察和正交设计筛选最优处方和工艺条件；考察了微丸的粉体学性质、收率和体外溶出效果。结果：用挤出滚圆技术制备的当归补血微丸圆整度好，大小均匀，收率高，体外溶出迅速。结论：挤出滚圆法可以制备中药微丸。该工艺简便易行，制得的微丸质量好。
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| 关 键 词： | 当归补血复方提取物 挤出滚圆法 微丸 粉体学性质 体外溶出 |
| 文章编号： | 1003-3734（2007）08-0625-04 |
Preparation and characterization of pellets for nourishing blood of Angelica sp. by extrusion-spheronization |
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| CHEN Hong-xia,JIA Xiao-bin,CHEN Yan,SHI Ya-fang,SUN Jing. Preparation and characterization of pellets for nourishing blood of Angelica sp. by extrusion-spheronization[J]. Chinese Journal of New Drugs, 2007, 16(8): 625-628 |
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| Authors: | CHEN Hong-xia JIA Xiao-bin CHEN Yan SHI Ya-fang SUN Jing |
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| Affiliation: | 1 School of Pharmacy, Jiangsu University, Zhenjiang 212001, China ; 2 Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, China |
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| Abstract: | Objective:To optimize the preparation and properties of the pellets for nourishing blood of Angelica sp.by spheronization of extruded masses.Methods:The pellets were prepared in a power-consumption-controlled twin-screw extruder,then spheronized and dried.The formulation and process was optimized by influential factors and orthogonal design.The micromeritic properties,yields and in vitro dissolution of the pellets were determined.Results:The pellets for nourishing blood of Angelica sp.were in homogenous size and spherical shape using the extrusion-spheronization equipment.The yields and in vitro dissolution were impressive.Conclusion:The extrusion-spheronization technique manufactures better quality of the Chinese herbal pellets. |
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| Keywords: | extracts of Angelica compound extrusion-spheronization pellet micromeritic prop-erty in vitro dissolution |
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