Modulation of the endogenous acetylcholine release from rat striatal slices |
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| Authors: | Jordi Alberch Jordi Marsal Carles Solsona |
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| Affiliation: | 2. Ministry of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, 644000, China;1. Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland;2. Western Washington University, USA |
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| Abstract: | The dopaminergic modulation of the acetylcholine release from rat striatal slices has been investigated using a chemiluminescent method. Dopamine, more efficiently than apomorphine, decreased the potassium-evoked release of acetylcholine. The effect of dopamine antagonists, haloperidol and sulpiride, has been studied, and haloperidol was a better antagonist than sulpiride to the dopamine effect. Haloperidol elicited an acetylcholine release from striatal slices at 0.1 nM, probably by removing endogenous dopamine from dopaminergic receptors. |
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| Keywords: | acetylcholine release potassium depolarization striatal slice dopaminergic agonist dopaminergic antagonist |
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