针灸调节脂联素在治疗肥胖型多囊卵巢综合征中的作用机制研究思路

多囊卵巢综合征(PCOS)是育龄女性常见的生殖内分泌疾病,肥胖和胰岛素抵抗(IR)被认为是PCOS病理生理过程中的中心环节。脂联素(APN)是近年来研究较多的与肥胖和IR相关的脂源性细胞因子。本文试图从APN与肥胖及IR相关性角度,探讨肥胖型PCOS的发病机制;同时对针灸调节APN的相关研究作一简要概述,以期为今后的临床针灸治疗PCOS提供一个新的方向。

Considerations about study on the underlying mechanism of acu-moxibustion in the treatment of obesity type polycystic ovary syndrome by regulating adiponectin

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of reproductive age, and the obesity and insulin resistance are considered to be the key link in the pathophysiological process of PCOS of obesity type. Adiponectin, a protein hormone, is closely related to insulin resistance and obesity, which has been being researched extensively in recent years. The authors of the present article review the pathogenesis of PCOS of obesity type from the relationship between adiponectin and obesity, and between adiponectin and insulin resistance, separately. In particular, the authors review studies on the underlying mechanism of acupuncture and moxibustion interventions in regulating adiponectin level briefly. The authors think of that acupuncture and moxibustion interventions induced increase of adiponectin level is possibly to improve insulin resistance in obesity and/or PCOS patients, hoping to provide a new target for clinical treatment of PCOS.