| 成人隐匿性自身免疫性糖尿病与HLA-DQ、DR基因的关联性 |
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| 引用本文： | 李强,潘红艳,陈莉丽,乔虹,孙玉倩,梁玮,张巾超.成人隐匿性自身免疫性糖尿病与HLA-DQ、DR基因的关联性[J].中华糖尿病杂志,2005,13(6):432-433,436. |
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| 作者姓名： | 李强 潘红艳 陈莉丽 乔虹 孙玉倩 梁玮 张巾超 |
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| 作者单位： | [1]哈尔滨医科大学附属二院内分泌代谢病科,150086 [2]现在黑龙江省伊春市第一医院内科工作,153000 |
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| 基金项目： | 哈尔滨市科技攻关项目基金资助项目（9814211018）、黑龙江省卫生厅科研课题资助项目（2001-024） |
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| 摘 要： | 探讨成人隐匿性自身免疫性糖尿病（LADA）与HLA-DQ、DR基因的关联性. 方法用聚合酶链反应序列特异性引物（PCR-SSP）检测60例正常人、41例1型糖尿病人（TlDM）和39例LADA患者的HLA-DR、DQ基因频率. 结果HLA-DR3、DR4、HLA-DQA1＊0301、HLA-DQB1＊0201与TlDM的易感性相关;HLA-DR15、HLA-DQB1＊0601与T1DM的保护性相关.HLA-DR4、HLA-DQA1＊0301、HLA-DQB1＊0201与LADA的易感性相关,HLA-DQB1＊0601的基因频率在LADA组中显著高于TlDM组（P＜0.05）. 结论不同的遗传背景可能是影响LADA和TlDM起病方式及病情进展的重要因素之一.
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| 关 键 词： | 糖尿病 1型 成人隐匿性自身免疫性糖尿病 HLA-DQ基因 HLA-DR基因 |
| 收稿时间： | 2005-07-25 |
| 修稿时间： | 2005-07-25 |
The relationship between latent autoimmune diabetes in adult(LADA) and HLA-DQ and DR gene |
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| LI Qiang,PAN Hong-yan,CHEN Li-li,et al..The relationship between latent autoimmune diabetes in adult(LADA) and HLA-DQ and DR gene[J].CHINESE JOURNAL OF DIABETES MELLITUS,2005,13(6):432-433,436. |
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| Authors: | LI Qiang PAN Hong-yan CHEN Li-li |
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| Institution: | LI Qiang,PAN Hong-yan,CHEN Li-li,et al.Department of Endocrinology & Metabolism,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China |
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| Abstract: | Objective The relationship between LADA and HLA-DQ and DR genes was studied. Methods The genotypes of HLA-DR and DQ in 60 healthy controls, 41 patients with type 1 diabetes, 39 patients with LADA were determined by PCR-SSP. Result (1)HLA-DR3,DR4,HLA-DQA1*0301,DQB1*0201 were positively associated with type 1 diabetes; HLA-DR15, HLA-DQB1*0601 were negatively associated with type 1 diabetes.(2)The frequencies of HLA-DR4,HLA-DQ*0301,HLA-DQB1*0201 were positively associated with LADA,and the frequencies of HLA-DQB1*0601 were significantly higher in LADA group than those in type 1 diabetic group. Conclusion Different genetic background may influence the progression of LADA and type 1 diabetes. |
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| Keywords: | Diabetes mellitus type 1 Latent autoimmune diabetes in adult HLA-DQ gene HLA-DR gene |
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