POEMS syndrome in a 24-year-old man associated with vitamin B12 deficiency and a solitary lytic bone lesion

We report one of the youngest cases of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes), presenting in a 24-year-old man. A solitary lytic bone lesion and vitamin B12 deficiency were also found. We suggest that this syndrome be considered in cases of subacute polyneuropathy developing in young adults. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1454–1456, 1997