Drugs of Abuse and Their Impact on Viral Pathogenesis |
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| Authors: | Jason T. Blackard Kenneth E. Sherman |
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| Affiliation: | 1.Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA;2.Center for Addiction Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA |
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| Abstract: | Commonly misused substances such as alcohol, cocaine, heroin, methamphetamine, and opioids suppress immune responses and may impact viral pathogenesis. In recent years, illicit use of opioids has fueled outbreaks of several viral pathogens, including the human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). This review focuses on the myriad of mechanisms by which drugs of abuse impact viral replication and disease progression. Virus–drug interactions can accelerate viral disease progression and lead to increased risk of virus transmission. |
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| Keywords: | drug use opioid HIV hepatitis B virus hepatitis C virus |
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