| 2型糖尿病患者血清中4种胰岛自身抗体检测的临床意义 |
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| 引用本文： | 毕永春,胡伟,张葵.2型糖尿病患者血清中4种胰岛自身抗体检测的临床意义[J].现代医学,2011,39(6):647-649. |
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| 作者姓名： | 毕永春 胡伟 张葵 |
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| 作者单位： | 南京大学医学院附属鼓楼医院检验科,江苏南京,210008 |
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| 摘 要： | 目的:探讨2型糖尿病(T2DM)患者血清谷氨酸脱羧酶抗体(GADA)、酪氨酸磷酸酶抗体(IA2)、抗胰岛细胞抗体(ICA)和抗胰岛素抗体(IAA)4种胰岛自身抗体检测的临床价值。方法:对978例T2DM患者和80例正常对照者血清中4种胰岛自身抗体进行检测、比较。结果:GADA、IAA、IA2和ICA在T2DM患者中的阳性率分别为7.1%、7.2%、3.3%和0.5%,联合检测总阳性率为16.0%,明显高于正常对照组3.8%的阳性率。GADA和IA2两种抗体联合检测阳性率为9.2%。T2DM患者中各抗体阳性较少重叠。结论:GADA和IA2两种抗体联合检测对检出T2DM中的成人隐匿性自身免疫性糖尿病(LADA)有重要指导价值,以利于对患者尽快采取有效措施保护胰岛B细胞功能,减少进一步的损伤。
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| 关 键 词： | 胰岛自身抗体 2型糖尿病 成人隐匿性自身免疫性糖尿病 |
Clinical value of 4 islet autoantibodies in type 2 diabetes |
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| BI Yong-chun,HU Wei,ZHANG Kui.Clinical value of 4 islet autoantibodies in type 2 diabetes[J].Modern Medical JOurnal,2011,39(6):647-649. |
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| Authors: | BI Yong-chun HU Wei ZHANG Kui |
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| Institution: | BI Yong-chun,HU Wei,ZHANG Kui (Department of Laboratory Medicine,Drum Tower Hospital,Nanjing University Medical School,Nanjing 210008,China) |
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| Abstract: | Objective: To explore the value of glutamic acid decarboxylase antibody(GAD-Ab),protein tyrosine phosphatase antibody-2(IA2),islet cell antibody(ICA)and insulin autoantibody(IAA)in type 2 diabetes.Methods: GAD-Ab,IA2,ICA and IAA were examined in 978 patients of type 2 diabetes mellitus(T2DM)and 80 normal controls.Results: The positive ratios of GADA,IAA,IA2 and ICA in T2DM were respectively 7.1%,7.2%,3.3% and 0.5%.The positive rate of combined test with the 4 autoantibodies reached to 16.0%,and significantl... |
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| Keywords: | autoantibodies to pancreatic islet cell type 2 diabetes latent autoimmune diabetes of adults |
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