广泛性焦虑障碍患者颅脑CT值特征研究

目的:探讨广泛性焦虑障碍(GAD)患者颅脑CT值的特征。方法:随机选择符合CCMD-3的GAD患者100例作为GAD组,选择性别年龄相匹配的健康人100人作为对照组,应用多层螺旋头颅CT检查测量两组对象各脑叶的CT值并进行比较。结果:(1)GAD组大脑左、右额叶脑组织密度CT值(分别为31.85±1.69、30.83±1.54)明显低于对照组(分别为34.46±1.65、34.50±1.65),均P<0.01;(2)在GAD组中,右侧额叶脑组织密度CT值较左侧额叶略低(P<0.01),对照组两侧额叶脑组织密度CT值差异无统计学意义(P>0.05)。结论:GAD患者大脑左右额叶脑组织密度CT值较正常人低,可能是大脑额叶功能损害的神经解剖学基础;焦虑情绪可以影响右侧额叶前部的皮质功能。

Study on characters of the value of brain CT in patients with generalized anxiety disorder

Objective: To investigate characteristics of brain CT value in patients with generalized anxiety disorder(GAD).Methods: 100 patients met the criteria of CCMD-3 generalized anxiety disorder were selected as the research group,and 100 sex and age matches were selected as control group.Two groups were measured with multi-slice spiral head CT and compared with each other.Results:(1) Left brain and right frontal lobe brain tissue CT density values in GAD group(respectively 31.85±1.69,30.83±1.54) were significantly lower than those in the control group(34.46±1.65,34.50±1.65)(both P<0.01).(2) In the GAD group,CT density of the right frontal lobe slightly lower value than the left frontal lobe(P<0.01);in control group,there were no significant differences of CT density values between right and left frontal lobe brain tissue(P>0.05).Conclusion: Both left and right frontal lobe brain tissue CT density values in patients with GAD are lower than those of controls,which might be responsible for the brain’s neural anatomy of frontal lobe dysfunction and anxious symptoms might affect on the right prefrontal cortex function.