| N5,10-亚甲基四氢叶酸还原酶基因多态性与宁夏回族原发性高血压的关系 |
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| 引用本文： | 刘海燕,陈淑萍,马萍,徐清斌.N5,10-亚甲基四氢叶酸还原酶基因多态性与宁夏回族原发性高血压的关系[J].天津医药,2011,39(12):1095-1098. |
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| 作者姓名： | 刘海燕 陈淑萍 马萍 徐清斌 |
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| 作者单位： | 宁夏医科大学附属医院心脏中心,银川,750004 |
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| 基金项目： | 宁夏同族自治区自然科学基金 |
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| 摘 要： | 目的:探讨N5,10-亚甲基四氢叶酸还原酶基因(MTHFR)C677T位点突变与宁夏回族人群原发性高血压(EH)之间的关系。方法:收集原发性高血压病患者(EH组)146例,健康体检正常血压者(NT组)112例,抽外周静脉血提取DNA,采用聚合酶链反应-限制性片段长度(PCR-RFLP)多态性技术检测MTHFR基因多态性。结果:EH组和NT组CC、CT和TT基因型总体分布频率差异有统计学意义(P<0.05),EH组TT基因型频率及T等位基因频率均高于NT组,差异有统计学意义(P<0.05)。CC基因型组和CT+TT基因型组舒张压差异无统计学意义(P>0.05),但收缩压、脉压和平均动脉压CT+TT基因型组高于CC基因型组,差异有统计学意义(P<0.05)。二元逐步Logistic回归结果显示,CT+TT基因型,女性,BMI、TG、BUN增高为EH的危险因素,GLU为保护因素。结论:MTHFR基因C677T多态性可能与宁夏回族EH发病有关,T等位基因有可能是宁夏回族人群EH的易感基因。
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| 关 键 词： | 限制性片段长度 |
The Association between Gene Polymorphisms of N5,10-Methylenetetrahydrofolate Reductase and Essential Hypertension in Patients of Ningxia Hui Nationality |
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| LIU Haiyan,CHEN Shuping,MA Ping,XU Qingbin.The Association between Gene Polymorphisms of N5,10-Methylenetetrahydrofolate Reductase and Essential Hypertension in Patients of Ningxia Hui Nationality[J].Tianjin Medical Journal,2011,39(12):1095-1098. |
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| Authors: | LIU Haiyan CHEN Shuping MA Ping XU Qingbin |
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| Institution: | LIU Haiyan,CHEN Shuping,MA Ping,XU Qingbin Cardiac Center,the Affiliated Hospital of Ningxia Medical University,Yinchuan 750004,China |
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| Abstract: | Objective:To investigate the association between C667T point mutation of N5,10-methylenetetrahydrofolate reductase (MTHFR) and essential hypertension in patients of Ningxia Hui nationality. Methods:The study was performed in 146 patients with essential hypertensive (EH) and 112 normotensive (NT) control subjects. Blood samples of two groups were collected and then DNA was extracted. MTHFR gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results... |
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| Keywords: | methylenetetrahydrofolate reductase(MTHFR) hypertension polymorphism genetic alleles gene frequency polymorphism restriction fragment length NINGXIA HUI NATIONALITY |
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