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| 非酒精性脂肪肝患者血清CK-18 M30水平的测定 | |
| 引用本文： | 董秋艳,韩涛,朱争艳,李岩,肖时湘,刘莹,刘欢,郭震.非酒精性脂肪肝患者血清CK-18 M30水平的测定[J].天津医科大学学报,2011,17(4):486-489. |
| 作者姓名： | 董秋艳 韩涛 朱争艳 李岩 肖时湘 刘莹 刘欢 郭震 |
| 作者单位： | 1. 天津医科大学三中心临床学院肝内科,天津,300170 2. 天津医科大学三中心临床学院肝内科,天津300170;天津市人工肝细胞重点实验室,天津300170 3. 天津市人工肝细胞重点实验室,天津,300170 |
| 基金项目： | 国家重点基础研究发展规划基金资助项目，科技部科技重大专项基金资助项目，天津市卫生局重点攻关资助项目 |
| 摘 要： | 目的：检测非酒精性脂肪肝（NAFLD）患者血清细胞角蛋白片段（CK-18M30）的水平，探讨其与患者生化指标的相关性。方法：采用ELISA法检测71例NAFLD患者血清CK-18M30的水平并与44例健康人比较。同时比较其中6例接受水飞蓟宾或多烯磷脂酰胆碱治疗好转前后患者血清CK-18 M30的水平。结果：NAFLD组患者血清CK-18 M30的浓度为（282．3743±184．7845）U／L，明显高于健康对照组的（100．0888±32．4828）U／L（P〈0．001）。通过腹部B超结合患者的临床症状及生化指标将71例患者分为轻度组、中度组、重度组，其血清CK-18M30的浓度分别为（148．6406±83．1094）U／L、（278．6333±142．6302）U/L与（471．2649±256．26571U／L，差异有统计学意义（P〈0．001）。NAFLD组患者血清CK-18M30的水平与血清中丙氨酸转氨酶呈正相关（r=0．449，P〈0．001）。6例治疗好转的NAFLD患者治疗后血清CK-18M30的水平（265．0840±130．0400）U／L]低于治疗前（435．9065±243．3389）U／L]，但其治疗前后差异没有统计学意义（P=0．160）。结论：NAFLD患者的血清CK-18 M30水平明显升高，对于判断NAFLD的严重程度具有一定价值。 |
| 关 键 词： | 非酒精性脂肪肝 血清细胞角蛋白片段（CK-18 M30） 凋亡 |
Serum CK-18 M30 levels in patients with nonalcoholic fatty liver disease |
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| DONG Qiu-yan,HAN Tao,ZHU Zheng-yan,LI Yan,XIAO Shi-xiang,LIU Ying,LIU Huan,GUO Zhen.Serum CK-18 M30 levels in patients with nonalcoholic fatty liver disease[J].Journal of Tianjin Medical University,2011,17(4):486-489. | |
| Authors: | DONG Qiu-yan HAN Tao ZHU Zheng-yan LI Yan XIAO Shi-xiang LIU Ying LIU Huan GUO Zhen |
| Institution: | DONG Qiu-yan 1,HAN Tao 1,2,ZHU Zheng-yan 2,LI Yan 1,XIAO Shi-xiang 1,LIU Ying 1,LIU Huan 1,GUO Zhen 1(1.Department of Gastroenterology,The Third Central Clinical College,Tianjin Medical University,Tianjin 300170,China,2.Tianjin Key Laboratory of Artificial Cell,China) |
| Abstract: | Objective: To investigate serum fragmented cytokeratin 18(CK-18 M30) levels in patients with nonalcoholic fatty liver disease(NAFLD).Methods: Serum CK-18 M30 levels were measured by ELISA in 71 patients with NAFLD and 44 healthy persons.In addition,the levels of serum CK-18 M30 in 6 patients who improved after received Silibinin or Polyene Phosphatidyl choline were investigated.Results: Compared with healthy control,serum CK-18 M30 levels of patients with NAFLD were significantly higher(P<0.001).The 71 pati... |
| Keywords: | Non-alcoholic fatty liver disease Serum fragmented cytokeratin 18(CK-18 M30) Apoptosis |
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