| 基质金属蛋白酶与出血性转化 |
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| 引用本文： | 杨晨辉,范洪光,刘莹,张祥建.基质金属蛋白酶与出血性转化[J].国际脑血管病杂志,2008,16(4). |
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| 作者姓名： | 杨晨辉 范洪光 刘莹 张祥建 |
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| 作者单位： | 河北医科大学第二医院神经内科,石家庄,050000 |
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| 摘 要： | 溶栓能有效治疗缺血性卒中,但有导致出血性转化的风险.许多研究显示,出血性转化与基质金属蛋白酶参与血脑屏障破坏、增加血管通透性密切相关.血浆MMP-9水平增高可作为出血性转化的独立预测因素.脑缺血早期应用基质金属蛋白酶抑制剂,有可能降低出血性转化的发生率和严重程度,但尚需进一步验证.
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| 关 键 词： | 基质金属蛋白酶 出血性转化 血脑屏障 |
Matrix Metalloproteinases and Hemorrhagic Transformation |
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| Chen-Hui Yang,Hong-Guang Fan,Ying Liu,Xiang-Jian Zhang.Matrix Metalloproteinases and Hemorrhagic Transformation[J].International Journal of Cerebrovascular Diseases,2008,16(4). |
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| Authors: | Chen-Hui Yang Hong-Guang Fan Ying Liu Xiang-Jian Zhang |
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| Abstract: | Thrombolysis can effectively treat ischemic stroke, but it has the risk of resulting in hemorrhagic transformation. A number of studies have suggested that hemorrhagic transforma-tion is closely correlated with matrix metalloproteinase mediated disruption of blood-brain barrier and the increase of vasopermeability. The increase plasma matrix metalloproteinase(MMP) -9 can be used as an independent predictor of hemorrhagic transformation. Using MMP inhibitors during the early cerebral ischemia may reduce the incidence and severity of hemor-rhagic transformation, however, it needs to be further validated. |
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| Keywords: | matrix metalloproteinase hemorrhagic transformation blood-brain barrier |
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