紫杉醇联合奈达铂术前辅助治疗局部晚期宫颈癌30例

目的: 探讨紫杉醇联合奈达铂方案术前辅助治疗局部晚期宫颈癌近期疗效。方法: 60例病理确诊的局部晚期宫颈癌患者, 30例术前采用1～2个疗程紫杉醇联合奈达铂方案的静脉化疗(化疗组), 之后全部行宫颈癌根治术;30例直接行手术治疗(对照组)。结果: 化疗组手术时间、术中出血量和胃肠功能恢复时间均少于对照组(P< 0.01), 淋巴结转移率低于对照组(P< 0.05)。结论: 紫杉醇联合奈达铂方案术前辅助治疗对局部晚期宫颈癌近期疗效显著, 可缩短手术时间及减少术中出血, 减少淋巴结转移, 降低术后并发症的发生率。

Effect of paclitaxel combined with nedaplatin in adjuvantthe chemotherapy treatment of locally advanced cervical cancer:a report of in 30 cases

Objective:To evaluate the short-term effects of paclitaxel combined with nedaplatin in the chemotherapy of locally advanced cervical cancer. Methods:Among 60 patients with locally advanced cervical cancer diagnosed by pathology, 30 cases (chemotherapy group) were treated with intravenous chemotherapy of paclitaxel combined with Cisplatin for 1 to 2 courses,then with radical hysterectomy of cervical cancer,other 30 cases were treated with direct surgical treatment( control group) . Results:The operation time,blood loss and recovery time of gastrointestinal function in chemotherapy group were less than those in control group(P<0. 01), the rate of lymph node metastasis in chemotherapy group was lower than that in control group(P < 0. 05). Conclusions:The preoperative chemotherapy of paclitaxel combined with nedaplatin in the treatment of locally advanced cervical cancer is good effects, which can significantly shrink the cervical masses, shorten operating time, and reduce blood loss, lymph node metastasis and postoperative complications.