胃癌组织中乳腺癌转移抑制基因1的表达及其临床意义

目的: 探讨乳腺癌转移抑制基因1(BRMS1)蛋白在胃癌组织中的表达及其临床意义。方法: 采用免疫组织化学法检测60例胃癌组织及相应癌旁组织60例中BRMS1蛋白的表达情况, 并分析其与各临床病理特征之间的关系。结果: 在胃癌组织中BRMS1蛋白低表达(35.0%), 在癌旁组织中高表达(75.0%), 差异有统计学意义(P<0.01);胃癌组织中BRMS1的表达水平在胃癌患者组织分化程度、淋巴结转移和临床分期间差异均有统计学意义(P<0.01),而在患者性别、年龄、浸润深度和肿瘤大小间差异均无统计学意义(P>0.05)。结论: BRMS1蛋白在胃癌组织中呈异常低表达, 且其低表达可能与胃癌的发生、发展以及浸润转移有一定关系。

Expression of breast cancer metastasis suppressor 1 in gastric carcinoma and relevant clinical significance

Objective:To investigate the expression of breast cancer metastasis suppressor 1(BRMS1) and its clinical significance in gastric carcinoma. Methods:The expression of BRMS1 in gastric carcinoma tissues(n=60) and para-cancerous tissues(n=60) was detected by immunohistochemiscal method. The relationship between the immunohistochemiscal results and the clinic pathologic parameters were analyzed. Results:The expression rate of BRMS1 in gastric carcinoma tissues(35. 0%)was significantly lower than that in para-cancerous tissues ( 75. 0%) ( P <0. 01 );there was the correlation between the expression of BRMS1 and the degree of differentiation,lymph node metastasis and clinical stages(P<0. 01),there was no correlation between the expression of BRMS1 and patient sex,age,infiltrative depth and size of tumor (P >0. 05). Conclusions:The BRMS1 protein was lower-expression in gastric carcinoma,which may be related with the tumor genesis,invasion and metastasis of gastric carcinoma.