Nonsyndromic X-linked mental retardation: review and mapping of MRX29 to Xp21 |
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| Authors: | B. Hä ne,R. J. Schroer,J. F. Arena,H. A. Lubs,C. E. Schwartz,R. E. Stevenson |
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| Affiliation: | J. C. Self Research Institute, Greenwood Genetic Center, Greenwood, South Carolina, USA.;Department of Pediatrics, Genetics Division, University of Miami, Miami, Florida, USA |
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| Abstract: | The gene responsible for nonsyndromic mental retardation in a family with 7 affected males has been localized to Xp21. The maximal two-point lod score was 3.31 for tight linkage to marker DXS1202 in Xp21.3-p22.3 with crossovers between the 3' portion of the DMD gene (DXS 1234) proximally and locus DXS989 distally. The XLMR gene in this family has been assigned the designation MRX29. The localization overlaps with at least six other MRX entities linked to the distal short arm of the X chromosome. |
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| Keywords: | linkage analysis mental retardation MRX29 X-chromosome |
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