| 汉防己甲素联合地塞米松对急性百草枯中毒的实验治疗研究 |
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| 引用本文： | 朱秋鸿,孟聪申,黄金祥.汉防己甲素联合地塞米松对急性百草枯中毒的实验治疗研究[J].中国工业医学杂志,2010,23(4):243-246+321. |
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| 作者姓名： | 朱秋鸿 孟聪申 黄金祥 |
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| 作者单位： | 中国疾病预防控制中心职业卫生与中毒控制所; |
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| 基金项目： | 中国疾病预防控制中心职业卫生所青年基金项目(06B0503) |
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| 摘 要： | 目的探讨汉防己甲素(tetrandrine,TET)和地塞米松(dexamethasone,DEX)联用对急性百草枯中毒所致肺损伤的拮抗作用。方法大鼠以百草枯(20 mg/kg)腹腔注射染毒后,治疗组经口给予TET(30 mg/kg)或腹腔注射DEX(3 mg/kg)或按上述两种药物的给药时间和剂量同时治疗,未治疗组腹腔注射生理盐水。观察每组动物的中毒表现和死亡结局。分别测定大鼠血浆丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力,并观察肺组织结构改变。结果(1)染毒1 d、3 d时,未治疗组血浆中MDA含量均高于对照组(P<0.05),1 d时血浆中SOD、GSH-Px活力均明显低于对照组(P<0.05);DEX治疗组各时间点血浆中MDA含量和SOD活力与未治疗组相似(P>0.05),1 d时血浆中GSH-Px活力高于未治疗组(P<0.05);TET治疗组除1 d时的GSH-Px活力高于未治疗组外,其余各时点与未治疗组基本一致(P>0.05);联合治疗组1d MDA含量、SOD和GSH-Px活力与未治疗组比较差异有统计学意义(P<0.05);(2)DEX治疗组和联合治疗...
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| 关 键 词： | 汉防己甲素 地塞米松 百草枯 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 |
Therapeutic effect of tetrandrine combined with dexamethasone on acute paraquat poisoning in rats |
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| ZHU Qiu-hong,MENG Cong-shen,HUANG Jin-xiang.Therapeutic effect of tetrandrine combined with dexamethasone on acute paraquat poisoning in rats[J].Chinese Journal of Industrial Medicine,2010,23(4):243-246+321. |
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| Authors: | ZHU Qiu-hong MENG Cong-shen HUANG Jin-xiang |
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| Institution: | ZHU Qiu-hong,MENG Cong-shen,HUANG Jin-xiang (National Institute of Occupational Health and Poison Control,Chinese Center for Disease Control and Prevention,Beijing 100050,China) |
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| Abstract: | Objective To explore the antagonistic effects of combined use of tetrandrine(TET) and dexamethasone(DEX) on lung injury induced by acute paraquat poisoning in rats.Methods 104 Wistar rats were randomly divided into experimental group(96 rats) and control group(8 rats),the experimental group was subdivided into 4 groups,non-treatment group,TET treatment group,DEX treatment group and combined treatment group,24 rats in each group.Rats in experimental groups were intraperitoneally given 20 mg/kg paraquat per d... |
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| Keywords: | tetrandrine dexamethasone paraquat malondialdehyde(MDA) superoxide dismutase(SOD) glutathione peroxidase(GSH-Px) |
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