Effects of adaptation to intermittent hypoxia on oxidative phosphorylation in brain mitochondria of rats with different sensitivities toward oxygen deficiency |
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Authors: | L D Luk'yanova G N Chernobaeva V E Romanova |
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Institution: | (1) Laboratory of Bioenergetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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Abstract: | After long-term adaptation to intermittent hypoxia, rats with an initially low resistance to acute oxygen deficiency were
2 to 4 times more resistant to it, while highly resistant rats did not show a significant change in resistance. The adaptation
was accompanied by weakening of the electron-transporting function of the respiratory chain and increasing efficiency of oxidative
phosphorylation in the brain mitochondria oxidizing NAD-dependent substrates, indicating that energy was produced in a more
economical way. The succinate oxidase pathway of oxidation was found to be utilized to only a limited extent as a compensatory
mechanism in animals exposed to intermittent hypoxia over a prolonged period. The effects of adaptation were more marked in
the brain mitochondria of rats initially highly sensitive to oxygen deficiency.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
12, pp. 572–575, December, 1995 |
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Keywords: | adaptation intermittent hypoxia individual resistance brain mitochondria oxidative phosphorylation NADH-oxidase oxidation succinate-oxidase oxidation |
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