Sequencing of two new HLA class II alleles: DRB3*0218 and DQB1*030202 |
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Authors: | Balas A Aviles M J Lillo R Alonso-Nieto M Zarapuz L García-Villaescusa R García-Sánchez F Vicario J L |
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Institution: | Histocompatibility Department, Regional Transfusion Center of Madrid, Madrid, Spain. abalas.trans@salud.madrid.org |
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Abstract: | Two novel human leukocyte antigen (HLA) class II alleles for DRB3 and DQB1 genes detected in Caucasoid Spanish individuals are described: DRB3*0218 and DQB1*030202. Both alleles have been found during routine high-resolution typing by sequencing. DRB3*0218 shows a novel DRB3 gene polymorphic position, located at amino acid residue 58, alanine to glutamic acid. This residue is shared by several DRB1 alleles, including all described DRB1*11 subtypes. DQB1*030202 differs from DQB1*030201 by a point mutation at position 319 (T to C). This nucleotide change generates a new codon at amino acid position 75 that is not shared by any other DQB1 allele. |
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Keywords: | DQB1*030202 DRB3*0218 SBT |
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