IL-1受体拮抗剂基因多态性与胃癌易感性的相关性研究

目的：探讨白细胞介素 1受体拮抗剂（interleukin 1 receptor antagonist gene IL 1ra）基因多态性与胃癌易感性的关系。方法: 应用聚合酶链式反应（PCR）技术和酶联免疫吸附试验（ELISA）对济南地区65例胃癌患者和71例健康对照IL 1ra基因多态性和幽门螺杆菌(helicobacter pylori Hp)进行分析。结果:与对照组相比，胃癌患者IL 1ra基因多态性差异无统计学意义（P>0.05）。在淋巴结转移、Hp阳性胃癌组与无淋巴结转移和Hp阴性胃癌组，IL 1ra基因多态性差异无统计学意义（P>0.05）。IL 1ra基因多态性与不同分化程度之间的胃癌患者无关。结论: 济南地区胃癌的易感性与IL 1ra基因多态性无关。

Relationship between polymorphisms of Interleukin-1 receptor antagonist gene and gastric cancer

Objective:To explore whether polymorphisms of interleukin-1 receptor antagonist(IL-1ra) gene has relation with gastric cancer.Methods: Seventy-one healthy controls and sixty-five patients with gastric cancer in Jinan were genotyped by polymerase chain reaction(PCR) for IL-1ra gene 86bp variable number of tandem repeat(VNTR) polymorphism of IL-1ra gene intron 2(for five different alleles).Result: IL-1ra gene polymorphisms were not statistically different between controls and patients with gastric cancer.And there was no difference between the lymph node metastasis and helicobacter pylori(HP)-positive group and the nonlymph node metastasis and HP-negative group.Conclusion: The results indicate that gastric cancer has association with IL-1ra genotype in Jinan individuals.