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| 黄连、吴茱萸及其药对对大鼠结肠异变腺窝的影响 | |
| 引用本文： | 周昕,董立,黄波,吴大正. 黄连、吴茱萸及其药对对大鼠结肠异变腺窝的影响[J]. 中国临床药理学与治疗学, 2011, 16(2): 143-147 |
| 作者姓名： | 周昕 董立 黄波 吴大正 |
| 作者单位： | 1. 上海中医药大学附属龙华医院药剂科,上海200032;上海中医药大学,上海201203 2. 山东省泰安市中心医院,泰安271000,山东 3. 上海中医药大学附属龙华医院药剂科,上海,200032 4. 上海中医药大学,上海,201203 |
| 摘 要： | 目的:研究黄连、吴茱萸及其药对对大鼠结肠癌前病变(异常腺窝病灶,aberrant crypt foci,ACF)的影响。方法:皮下注射二甲肼(1,2-di m-ethylhydrazine,DMH)诱发大鼠结肠ACF形成,根据形态法观察亚甲蓝染色后ACF在结肠上皮的数量和分布变化。同时通过测定肝重指标评估药物对肝的损伤情况。结果:与模型组相比,黄连、吴茱萸及其药对在大剂量和中剂量时,都能明显抑制ACF形成(P<0.01);在小剂量时,黄连组亦能抑制ACF形成(P<0.05);黄连大、中剂量组和吴茱萸大剂量组的肝重指数有所增加(P<0.01),而药对组的肝重指数小于黄连组及吴茱萸组,且3给药组间有统计学差异(P<0.01)。结论:黄连、吴茱萸及其药对在一定程度上能抑制ACF形成,且配伍后能减轻对肝的损伤。 |
| 关 键 词： | 黄连 吴茱萸 黄连吴茱萸药对 异常腺窝病灶 |
Influence of huanglian,wuzhuyu and huanglian-wuzhuyu pair herbs on aberrant crypt foci(ACF)in rat colon |
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| ZHOU Xin,DONG Li,HUANG Bo,WU Da-zheng. Influence of huanglian,wuzhuyu and huanglian-wuzhuyu pair herbs on aberrant crypt foci(ACF)in rat colon[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 143-147 | |
| Authors: | ZHOU Xin DONG Li HUANG Bo WU Da-zheng |
| Affiliation: | ZHOU Xin1,2,DONG Li3,HUANG Bo1,WU Da-zheng21Longhua Hospital Affiliated to Shanghai University of the Traditional Chinese Medicine,Shanghai 200032,China,2Shanghai University of the Traditional Chinese Medicine,3Taian Central Hospital,Shandong Province,Taian 271000,Shandong,Chin |
| Abstract: | AIM: To study the influence of huanglian,wuzhuyu and huanglian-wuzhuyu pair herb on aberrant crypt foci(ACF) in rat colon. METHODS: DMH(1,2-dimethylhydrazine) was injected subcutaneously to induce ACF in rat colon.According to morphologic criteria,the ACF's frequencies and position were observed after stained with methylene blue,and live dysfunction induced by medicines were evaluated by liver weight index.RESULTS:The numbers of ACF were significantly decreased by huanglian,wuzhuyu and huanglian-wuzhuyu pai... |
| Keywords: | Huanglian Wuzhuyu Huanglian-wuzhuyu pair herb Aberrant crypt foci 1 2-dimethylhydrazine |
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