| 依达拉奉注射液治疗急性缺血型脑梗死有效性的临床评价 |
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| 引用本文： | 严蓉,李战,杨修庚,于锋. 依达拉奉注射液治疗急性缺血型脑梗死有效性的临床评价[J]. 中国临床药理学与治疗学, 2011, 16(2): 190-195 |
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| 作者姓名： | 严蓉 李战 杨修庚 于锋 |
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| 作者单位： | 1. 中国药科大学临床药学教研室,南京210009,江苏
2. 南京长澳医药科技有限公司,南京210000,江苏 |
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| 摘 要： | 目的:评价依达拉奉注射液治疗急性缺血型脑梗死的有效性。方法:采用多中心、随机双盲、安慰剂平行对照联合基础用药的研究方法,以0.9%NaCl注射液为安慰剂,依达拉奉注射液为试验药,每次20 mL/支加生理盐水100 mL静脉滴注,一日2次,疗程为14 d。结果:本研究共入组病例238例,其中试验组119例,安慰剂组119例。试验组患者,接受依达拉奉注射液治疗以后,自治疗第7天起,神经功能评分即优于安慰剂组,差异有统计学意义(P<0.01)。随着时间的延长,两组间差异显著增加。结论:依达拉奉注射液是一种治疗急性缺血型脑梗死的有效药物。
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| 关 键 词： | 依达拉奉注射液 自由基清除剂 脑梗死 Ⅱ期临床试验 |
Efficacy of edaravone injection in treatment of acute ischemic stroke |
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| YAN Rong,LI Zhan,YANG Xiu-geng,YU Feng. Efficacy of edaravone injection in treatment of acute ischemic stroke[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 190-195 |
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| Authors: | YAN Rong LI Zhan YANG Xiu-geng YU Feng |
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| Affiliation: | YAN Rong1,LI Zhan2,YANG Xiu-geng2,YU Feng11Clinical Pharmaceutical Department of China Pharmaceutical University,Nanjing 210009,Jiangsu,China,2C&O Pharmaceutical Technology(Holdings)Limited,Nanjing 210000,Jangsu |
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| Abstract: | AIM: To evaluate the clinical efficacy of edaravone injection in patients with acute ischemic stroke. METHODS: A multicenter,randomized,double blind,placebo controlled,parallel and combined with basic medicals trial was carried out on patients with acute ischemic stroke.Beside the basic treatments,the patients in treatment group were received edaravone 20 mg dissolved in sodium chloride injection 100 mL,twice a day,for 14 days,while that of control group were received similar quantity of sodium chloride inj... |
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| Keywords: | Earavone injection Free radical scavenger Acute ischemic stroke Phase II clinical trial |
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