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| 双系表型急性白血病的免疫分型特点及疗效分析 | |
| 引用本文： | 张婧婧,张楠,张新富,石瑛,王辉. 双系表型急性白血病的免疫分型特点及疗效分析[J]. 中国实验血液学杂志, 2011, 19(2): 317-320 |
| 作者姓名： | 张婧婧 张楠 张新富 石瑛 王辉 |
| 作者单位： | 1. 新乡医学院医学检验系,河南,新乡,453003 2. 新乡医学院医学检验系教务处,河南,新乡,453003 3. 新乡医学院医学检验系三全学院,河南,新乡,453003 4. 郑州大学第三附属医院,河南,郑州,450007 |
| 摘 要： | 本研究探讨双表型急性白血病(biphenotypic acute leukemia,BAL)的免疫分型特点及疗效分析。采用流式细胞术四色免疫荧光直接标记技术与CD45/SSC设门分析技术检测45例疑似BAL患者,根据欧洲白血病免疫分类组(EGIL)积分标准进行分型。结果表明,45例疑似BAL患者中My/B-ALL的有23例,均共同表达cCD79a和cMPO,胞膜抗原CD19表达量最高,其次为CD10;My/T-ALL有18例,均共同表达cCD3和cMPO,胞膜中CD7表达最高,其次为CD5;T系和B系抗原共同表达的有4例,均共同表达cCD3和cCD79a。BAL患者中30例表达cTdT,25例表达CD34,31例表达CD117;My/B-ALL与My/T-ALL患者抗原表达中,CD33表达率高于CD13。CD34+的My/B-ALL的CR率低于CD34-My/B-ALL的CR率,CD34+My/T-ALL的CR率低于CD34-My/T-ALL的CR率。结论:双表型急性白血病以My/B-ALL系抗原共同表达最常见,其次为My/T-ALL。cCD3、cCD79a、cMPO对诊断及鉴别双表型急性白血病极为重要。流式细胞术是诊断双表型急性白血病最特异的方法。低分化细胞的BAL的临床预后不佳。 |
| 关 键 词： | 双表型急性白血病 免疫分型 流式细胞术 |
Immunophenotyping Characteristics of Biphenotypic Acute Leukemia and Analysis of Curative Effect |
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| ZHANG Jing-Jing,ZHANG Nan,ZHANG Xin-Fu,SHI Ying,WANG Hui. Immunophenotyping Characteristics of Biphenotypic Acute Leukemia and Analysis of Curative Effect[J]. Journal of experimental hematology, 2011, 19(2): 317-320 | |
| Authors: | ZHANG Jing-Jing ZHANG Nan ZHANG Xin-Fu SHI Ying WANG Hui |
| Affiliation: | ZHANG Jing-Jing,ZHANG Nan1,ZHANG Xin-Fu2,SHI Ying3,WANG Hui Department of Medical Laboratorial Examination,1Education Administration,2Sanquan School of Xinxiang Medical College,Xinxiang,453003,Henan Province,China,3The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450007 |
| Abstract: | This study was aimed to investigate the immunophenotyping characteristics of biphenotypic acute leukemia(BAL) and to analyze its curative efficacy.The four-color direct immunofluorescence staining and CD45/SSC gating analysis of flow cytometry were used to detect the cells of bone marrow and peripheral blood of 45 doubtful cases of BAL,and the immunophenotyping was performed according to the European Group for the Immunological Classification of Leukemia(EGIL) score criterion.The results showed that among 4... |
| Keywords: | biphenotypic acute leukemia immunophenotype flow cytometry |
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