戊聚硫钠对慢性非细菌性前列腺炎大鼠动物模型治疗的研究

目的:探讨戊聚硫钠(PPS)对慢性非细菌性前列腺炎(CNP)大鼠的治疗作用。方法:选取6月龄健康成年雄性SD大鼠80只,体重315~450 g,去势后用苯甲酸雌二醇0.25 mg/(kg.d)皮下注射,每日1次,连续注射30 d建模。成功建立CNP大鼠动物模型后,随机等分为安慰剂组和PPS治疗组,每组40只,分别用PPS、生理盐水灌胃治疗,连续8周后,处死动物,前列腺组织,HE染色,观察其病理变化。结果:建模后各组大鼠前列腺出现不同程度的慢性炎症改变和炎症细胞的浸润。PPS治疗组大鼠前列腺炎症较治疗前明显好转,而安慰剂组炎症未见好转。结论:PPS对大鼠CNP有一定治疗作用,其作用机制可能与PPS可修复大鼠前列腺受损的GAG层,抑制炎症的发生相关。

Pentosan polysulfide sodium for chronic non-bacterial prostatitis in the rat model

Objective： To investigate the therapeutic effect of pentosan polysulfide sodium （PPS） on chronic non-bacterial prostatitis （CNP） in rats. Methods ： Based on Robinette＇s method, we established a CNP model in 80 male SD rats, aged 6 months and weighing 315 -450 g, by castration followed by subcutaneous injection of estradiol at 0.25 mg/ （kg· d） for 30 consecutive days. Then we randomly allocated the model rats into a placebo group （n = 40） and a PPS group （n = 40） to receive intragastric administration of normal saline and PPS, respectively. After 8weeks of treatment, the pathological changes in the rat prostatic tissue were ob- served by HE staining. Results ： Varied degrees of chronic inflammation and inflammatory cell infiltration were seen in the prostatic tissues of both groups of rats before the treatment. The inflammation was significantly improved after the treatment in the PPS group but not in the placebo group. Conclusion ： PPS has some therapeutic effect on CNP in the rat, and its mechanism may be associated with the abilities of PPS to repair the damaged glycosaminoglycan layer and inhibit inflammation in the prostate.