| 氯胺酮对神经病理性痛大鼠海马CA1区突触长时程增强的影响 |
| |
| 引用本文： | 魏辉明,麻伟青,杨云丽,董发团,张承华,王慧明. 氯胺酮对神经病理性痛大鼠海马CA1区突触长时程增强的影响[J]. 中国临床药理学与治疗学, 2011, 16(2): 170-173 |
| |
| 作者姓名： | 魏辉明 麻伟青 杨云丽 董发团 张承华 王慧明 |
| |
| 作者单位： | 成都军区昆明总医院麻醉科,昆明650032,云南 |
| |
| 摘 要： | 目的:探讨氯胺酮对神经病理性痛大鼠海马CA1区突触长时程增强(LTP)的影响。方法:成年雄性Wistar大鼠18只,体重190~220 g,随机分为3组(n=6):神经病理性痛模型组、假手术组、氯胺酮组。采用结扎L4,5左侧脊神经的方法制备大鼠神经病理性痛模型。于模型制备后1周、2周和3周观察大鼠痛行为学及足部形态;于模型制备前、后1周、2周和3周时测定痛阈;于最后一次痛阈测定结束后3 d记录海马CA1区兴奋性突触后电位(EPSP),以高频刺激(HFS)诱发LTP,氯胺酮组HFS前20 min经腹腔注射25 mg/kg。结果:与假手术组比较,模型组和氯胺酮组各时点痛阈降低;与模型组相比,氯胺酮组LTP程度减弱(P<0.01)。结论:氯胺酮可抑制神经病理性痛对大鼠海马CA1区突触LTP的易化作用。
|
| 关 键 词： | 神经痛 长时程增强 海马 氯胺酮 |
Effect of ketamine on synaptic long-term potentiation in hippocampus in rats with neuropathic pain |
| |
| WEI Hui-ming,MA Wei-qing,YANG Yun-li,DONG Fa-tuan,ZHANG Chen-hua,WANG Hui-ming. Effect of ketamine on synaptic long-term potentiation in hippocampus in rats with neuropathic pain[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 170-173 |
| |
| Authors: | WEI Hui-ming MA Wei-qing YANG Yun-li DONG Fa-tuan ZHANG Chen-hua WANG Hui-ming |
| |
| Affiliation: | WEI Hui-ming,MA Wei-qing,YANG Yun-li,DONG Fa-tuan,ZHANG Chen-hua,WANG Hui-ming Department of Anesthesiology,Kunming General Hospital of Chengdu Military Area,Kunming 650032,Yunnan,China |
| |
| Abstract: | AIM: To investigate the effect of ketamine on synaptic long-term potentiation(LTP) in the hippocampus in rats with neuropathic pain. METHODS: Eighteen adult male Wistar rats weighing 190-220 g were randomly divided into three groups(n=6): model of neuropathic pain group(model group),sham operating group,and ketamine group.Neuropathic pain was produced by ligation of the left L4,5 spinal nerve.The behaviour of the rats was evaluated at 1,2 and 3 week after surgery.The pain threshold was measured before surge... |
| |
| Keywords: | Neuralgia Long-term potentiation Hippocampus Ketamine |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
