| 干细胞向雄性配子诱导分化研究进展 |
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| 引用本文： | 李朋,胡洪亮. 干细胞向雄性配子诱导分化研究进展[J]. 中华男科学杂志, 2011, 17(4): 356-360 |
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| 作者姓名： | 李朋 胡洪亮 |
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| 作者单位： | 上海交通大学医学院附属仁济医院泌尿外科,上海市男科学研究所精子发育与遗传学实验室,上海市人类精子库,上海200001 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，上海市教委重点课题，上海交通大学医学院自然基金课题 |
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| 摘 要： | 人类雄性配子的重要功能之一是完整地将父代遗传信息传递给子代。配子发生,尤其雄性配子发生是个极其复杂的细胞分化过程,它包括有丝分裂与减数分裂两大过程。然而由于缺乏可重复、高效率研究雄性配子发生的体外培养体系,生殖细胞发生、发育机制研究进展缓慢。干细胞经体外诱导向雄性生殖细胞分化的研究,将推进生殖细胞发育研究,甚至生殖生物学的发展。本文综述近年原始生殖细胞体外培养及干细胞向雄性配子诱导分化的研究进展。
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| 关 键 词： | 雄性生殖细胞 干细胞 分化 |
Advances in the study of the differentiation of stem cells into male gametes |
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| LI Peng,HU Hong-liang. Advances in the study of the differentiation of stem cells into male gametes[J]. National Journal of Andrology, 2011, 17(4): 356-360 |
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| Authors: | LI Peng HU Hong-liang |
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| Affiliation: | LI Peng,HU Hong-liang,LI ZhengDepartment of Urology,Renji Hospital,Shanghai Jiaotong University School of Medicine,Laboratory for Sperm Development and Genetics,Shanghai Institute of Andrology,Shanghai Human Sperm Bank,Shanghai 200001,China |
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| Abstract: | Male gametes play a critical role in transmitting hereditary information to the offspring.Gametogenesis,especially spermatogenesis,is a complicated differentiation process including mitosis and meiosis.However,for lack of an efficient and reproducible model,the mechanism of male germ development is not yet clear.Researches on stem cells' differentiation into male gamates in vitro will promote the study of germ cell development and even reproductive biology.This article updates the researches on the culture ... |
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| Keywords: | male germ cell stem cell differentiation |
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