| 苦参、山豆根植物中主要生物碱药学研究进展 |
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| 引用本文： | 戴五好,钱利武,杨士友,周国勤. 苦参、山豆根植物中主要生物碱药学研究进展[J]. 安徽医药, 2011, 15(9): 1057-1060 |
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| 作者姓名： | 戴五好 钱利武 杨士友 周国勤 |
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| 作者单位： | 安徽中医学院,安徽,合肥,230031;安徽省药物研究所,安徽,合肥,230022;安徽省药品评审中心,安徽,合肥,230022 |
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| 基金项目： | 长三角地区科技联合攻关项目，安徽省高层次人才创新创业资金 |
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| 摘 要： | 该文综述了药用植物苦参、山豆根主要生物碱分离纯化及含量测定研究进展.对近年来国内外发表的相关文献进行收集、分析整理及归纳.现有文献多为苦参总碱的纯化,而涉及单体生物碱的分离较少;在含量测定方面多以苦参碱、氧化苦参碱等为质控指标,不尽合理.应加强对苦参、山豆根中生物碱的结构多样性、毒理及构效关系等研究,以扩大这类植物活性...
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| 关 键 词： | 苦参 山豆根 生物碱 |
Advance in pharmaceutical research of main alkaloid in Sophora flavescens and Sophora tonkinensis |
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| DAI Wu-hao,QIAN Li-wu,YANG Shi-you,ZHOU Guo-qin. Advance in pharmaceutical research of main alkaloid in Sophora flavescens and Sophora tonkinensis[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(9): 1057-1060 |
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| Authors: | DAI Wu-hao QIAN Li-wu YANG Shi-you ZHOU Guo-qin |
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| Affiliation: | 1.College of Pharmacy,Anhui College of Traditional Chinese Medicine,Hefei,Anhui 230031,China;2.Anhui Institute of Materia Medica,Hefei,Anhui 230022,China;3.Center for Drug Evaluation in Anhui Province,Hefei,Anhui 230022,China) |
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| Abstract: | Many extracted purification and determination methods of main alkaloids in S.flavescens and S.tonkinensis medical plants have been summarized.The relevant articles published in recent years were collected,analyzed,arranged and concluded.The existing literature are mostly purification of total Sophora alkaloids,however,the separation of monomer alkaloids are less.The determination of matrine,oxymatrine as quality control indicators is not reasonable in S.flavescens and S.tonkinensis plants.The structure diversity,toxicology and structure-activity relationship of those alkaloids should be strengthened in order to utilize resources and ensure safety and validity of clinical using for S.flavescens and S.tonkinensis plants. |
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| Keywords: | Sophora flavescens Sophora tonkinensis alkaloid |
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