Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients |
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Authors: | R Feder |
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Affiliation: | Nashua Brookside Hospital, N.H. |
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Abstract: | Three male patients are described in whom anorgasmia developed during treatment with fluoxetine for depression. During attempts to treat the anorgasmia with cyproheptadine, all three patients suffered a relapse of depressive symptoms. The possible mechanism of this effect is discussed in relation to serotonergic systems. |
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