乳腺癌组织微阵列HER-2/neu,ER,PR相关性的研究

目的构建乳腺癌组织微阵列,研究HER-2/neu,雌激素受体(estrogen receptor,ER)、孕激素受体(progestogen receptor,PR)在原发性乳腺癌中的表达及其相关性.方法应用组织微阵列仪制作乳腺癌组织微阵列(tissue mieroarray).用免疫组织化学方法检测HER-2/neu,ER,PR在180例乳腺癌中的表达.结果180例乳腺癌肿瘤组织中HER-2/neu,ER,PR阳性率分别为37.8,38.3和47.2,HER-2/neu表达与激素受体(hormone receptor,HR)呈负相关,而与ER,PR无明显相关性.在激素受体和HER-2/neu均阳性的患者中,HER-2/neu与HR蛋白表达水平也呈负相关.结论乳腺癌细胞HER-2/neu表达及表达水平与HR表达及表达水平负相关.同时检测HER-2/neu,ER,PR对乳腺癌的辅助治疗具有重要意义及实用价值.

Study on association between HER- 2/neu and ER, PR in primary breast cancer microarray

Objective:To develop tissue microarray of breast cancer,and investigate the role of HER-2 /neu,ER,PR in the breast cancer of benign lesion and it's relation.Met hods:Tissue microarray of breast cancer was constructed by using a micro array. The expression of HER-2/neu,ER,PR was detected on the section of tissue microarray by immunohistochemistry.Results:Breast cancer tissue microarray was developed. The positive rate of the expression of HER-2/neu,ER,PR in 180 cases with breast cancer is 37.8%,38.3%,47.2%,respectively. Expres sion of HER-2/neu is inversely correlated with HR but not ER,PR expression resp ectively. Despite the general inverse association between them,33 cases (18.3%) are both HER-2/neu and hormone receptor(HR) position. In these cases,the lever s of HER-2/neu overexpression were inversely correlated with HR levers too. Conclusions: The expression and expressive levers of HER-2/neu are i nversely correlated with that of HR o To test HER-2/neu,ER,PR at the same time is very important for the treatment of breast cancer.