Poly-L-lactic acid: a new dimension in soft tissue augmentation |
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Authors: | Rotunda Adam M Narins Rhoda S |
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Affiliation: | Department of Dermatology, Mohs Micrographic Surgery and Cutaneous Oncology, Bennett Surgery Center, University of Southern California Keck School of Medicine, USA. arotunda@hotmail.com |
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Abstract: | Poly-L-lactic acid (PLLA) is a biodegradable, synthetic polymer of L-lactic acid that has been used in a variety of human medical applications for over 40 years. It has recently been approved in the United States for the treatment of HIV-associated facial lipoatrophy. This indication, combined with a European experience that indicates a clinical benefit persisting for up to 2 years, has made PLLA an increasingly popular injectable soft tissue filler in healthy patients. However, controlled clinical studies are necessary to determine whether PLLA benefits healthy patients seeking contour restoration as much as patients seeking treatment for HIV facial lipoatrophy. The present authors reviewed the background and clinical applications of PLLA as treatment for HIV-associated facial lipoatrophy and age-related facial volume loss. |
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Keywords: | cosmetic dermatology HIV lipoatrophy poly-l-lactic acid Sculptra soft tissue augmentation |
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