Decreased antinociceptive effect of morphine in rats treated intraventricularly with prostaglandin E1 |
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| Authors: | S. Ferri A. Santagostino P. C. Braga I. Galatulas |
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| Affiliation: | (1) Institute of Pharmacology, Laboratory of Toxicology, Faculty of Sciences, University of Milan, Italy |
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| Abstract: | The administration of prostaglandin E1 intracerebrally through a cannula implanted in a lateral ventricle, antagonizes morphine analgesia in rats.An electrical stimulation technique was adopted on the rat's tail to measure the antinociceptive activity of morphine. Some hypotheses are advanced in order to explain the sensitizing activity of prostaglandin E1. |
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| Keywords: | Prostaglandin E1 Analgesia Morphine |
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