| 固本延衰方对亚急性衰老模型小鼠IL-2及其受体表达的影响 |
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| 引用本文： | 王敏,王平,韩永明,洪小平,段妍君,邹峰. 固本延衰方对亚急性衰老模型小鼠IL-2及其受体表达的影响[J]. 云南中医学院学报, 2005, 28(4): 40-42 |
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| 作者姓名： | 王敏 王平 韩永明 洪小平 段妍君 邹峰 |
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| 作者单位： | 1. 湖北中医学院基础医学部,湖北,武汉,430061
2. 广州军区武汉总医院肾内科,广东,广州,430070 |
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| 基金项目： | 湖北省教育厅资助青年课题(NO:2003B00001)，湖北省卫生厅资助课题 |
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| 摘 要： | 目的:探讨固本延衰方延缓亚急性衰老模型小鼠衰老的机制。方法:将60只小鼠随机分为4组,除正常对照组外均皮下注射D-半乳糖造成衰老模型,并给予不同剂量的固本延衰方治疗,分别用放免法及流式法测定脾淋巴细胞白细胞介素2及其受体水平。结果:衰老模型组IL-2及其受体水平明显低于正常对照组(P<0.05),固本延衰方各剂量组IL-2及其受体水平明显高于衰老模型组(P<0.05,P<0.01)。结论:提示固本延衰方通过提高衰老机体淋巴细胞IL-2及其受体表达水平,从而调节机体免疫功能延缓衰老。
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| 关 键 词： | 固本延衰方 D-半乳糖 衰老 IL-2 IL-2R |
| 文章编号： | 1000-2723(2005)04-0040-03 |
| 收稿时间： | 2005-04-19 |
| 修稿时间： | 2005-10-08 |
Effect of GuBenyanshuai Recipe on Subacute Modle Mice and It''''s Receptor Expression |
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| WANG Min,WANG Ping,HAN Yong-ming,HONG Xiao-ping,DUAN Yan-jun,ZHOU Feng. Effect of GuBenyanshuai Recipe on Subacute Modle Mice and It''''s Receptor Expression[J]. Journal of Yunnan College of Traditional Chinese Medicine, 2005, 28(4): 40-42 |
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| Authors: | WANG Min WANG Ping HAN Yong-ming HONG Xiao-ping DUAN Yan-jun ZHOU Feng |
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| Affiliation: | 1. Hubei College of TCM, Wuhan Hubei 430061, China; 2. Wuhan Hospital of Guangzhou Military Subarrea |
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| Abstract: | Objective:To research the mechanism of GuBenYanShuai recipe to postpone the senescence of the subacute aging modle mice.Methd:divide 60 mices into 4 groups.make aging model using D-glucose subcutaneous injection except the control group.After theraping with different dosage GBYSR detect the spleen lymphocyte IL-2 and IL-2R in radio-immunity assay and Flow cells assay respectivly.Result:the level of Il-2 and IL-2R in model group is lower than control group(P<0.05),the level of Il-2 in maximums dosage of GBYSR group is higher than model group(P<0.05,P<0.01).Conclution:imply that GBYSR could postpone aging from improving the level of IL-2 then regulating the body's immune function. |
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| Keywords: | GBYSR D-glucose Aging IL-2 IL-2R |
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