Supportive evidence for contribution of the dopamine D2 receptor gene to heritability of stature: linkage and association studies |
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| Authors: | T. ARINAMI Y. IIJIMA K. YAMAKAWA-KOBAYASHI H. ISHIGURO T. OHTSUKI H. YANAGI Y. SHIMAKURA H. ISHIKAWA H. HAMAGUCHI |
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| Affiliation: | Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan;Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan;Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305–8575, Japan |
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| Abstract: | Increases in height were reported in children chronically exposed prenatally and postnatally to D2 receptor-blocking drugs. A possible haplotypic association between stature and the DRD2 gene was also reported. In this study, we examined linkage between stature and DRD2 by genotyping a dinucleotide repeat polymorphism in 79 sib-pairs aged 8–17 years. An association between stature and a putative functional polymorphism in the promoter region of the DRD2 gene was examined in the sib-pairs and in 125 unrelated male adults. All the subjects were Japanese. Linkage ( p = 0.004, SIBPAL) and an association ( p = 0.009, paired t -test, in the sib-pairs; p = 0.006, ANOVA, in the adults) with stature were suggested. These findings indicate that DRD2 is one of the genes that contribute to heritability of stature. |
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