Further studies on the interaction of Toxoplasma gondii with neutrophils and eosinophils |
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| Authors: | MacLaren A De Souza W |
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| Affiliation: | Laboratory of Cellular Ultrastructure Hertha Meyer, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Brazil. |
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| Abstract: | Tachyzoites of Toxoplasma gondii are ingested by neutrophils and eosinophils through a process which can be significantly inhibited by previous incubation of the host cells with cytochalasin D. Although dividing zoites within the leukocytes could be observed, after 3 h of infection, killing of parasites within the parasitophorous vacuole was detected. Cytochemical studies showed that both in neutrophils and eosinophils there is a process of NADP(H) oxidase activation, which was higher in the latter. |
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