他汀类药物对慢性肾功能衰竭患者炎性反应的影响

目的 观察慢性肾功能衰竭(CRF)患者C-反应蛋白(CRP)、纤维蛋白原(Fg)的变化,探讨他汀类药物对CRF患者炎性反应的影响.方法 将54例CRF患者随机平均分为两组:非他汀组予常规治疗;他汀组予常规治疗加普伐他汀20 mg/d或辛伐他汀20 mg/d.同时设健康对照组20例.测定各组治疗前和治疗4周后CRP、Fg水平.结果 CRF患者治疗前CRP、Fg显著高于对照组,差异有统计学意义(P＜0.05).治疗4周后,他汀组CRP、Fg水平下降,与治疗前及同期非他汀组相比,差异有统计学意义(P＜0.05).结论 (1)CRF患者中存在CRP水平升高的炎性反应;(2)他汀类药物可以降低CRP、Fg水平,提示其具有降脂以外的抗炎作用.

Effects of statins on inflammatory reaction in chronic renal failure patients

Objective To observe the changes of serum CRP and plasma Fg in patients with chronic renal failure(CRF),to explore the effect of statins on inflammaory reaction in CRF patients.Methods 54 patients with CRF were randomly divided into non-statins group(routine therapy);atstina group(routine therapy plus simvastatin 20mg/d or pravastatin 20mg/d).Besides,a healthy control group consisted of 20 subjects was set up as control group.The changes of serum of CRP and plasma Fg of all groups before and four weeks after treatment were recorded.Results The serum CRP and plasma Fg levels increased in CRF patients,Which were significantly higher as compared to the control group.After treatment for four weeks,the level of CRP,Fg of matins group decreased significantly.The levels of CRP,Fg had no statistical changes in non-statins group.As compared to non-statins group,the differences of CRP,Fg levels after treatment in statins group were statistically significant respectively.Conclusions(1)Inilammaory reaction is a common condition in non-dialysis patients with CRF;(2)ststins show effects on decrease of CRP,Fg level in CRF patients,independently on the effect of decreasing hypedipemia.