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拉莫三嗪对海洛因依赖者抑郁及焦虑障碍的治疗作用
引用本文:刘晓滨,宋志彬.拉莫三嗪对海洛因依赖者抑郁及焦虑障碍的治疗作用[J].中国药物滥用防治杂志,2006,12(6):326-328.
作者姓名:刘晓滨  宋志彬
作者单位:1. 深圳市公安局强制戒毒所,深圳,518019
2. 中山市小榄人民医院,中山,528415
摘    要:目的:确定拉莫三嗪治疗海洛因依赖者抑郁、焦虑障碍的效果。方法:符合CCMD-2-R海洛因依赖者伴发焦虑症、抑郁性神经症诊断标准的72例病人随机分为2组,拉莫三嗪组及黛力新组(对照组),治疗前、治疗后1周末、3周末、5周末对两组病人进行HAMD及HAMA评分。结果:拉莫三嗪组的抗抑郁及焦虑作用于用药后第5周效果明显,用药后第1周及第3周其抗抑郁不如黛力新(P<0.05),而用药后第5周与黛力新无明显差异(P>0.05)。结论:拉莫三嗪有效地缓解海洛因依赖者焦虑抑郁障碍。

关 键 词:拉莫三嗪  海洛因依赖  抑郁  焦虑
收稿时间:2006-05-17
修稿时间:2006-05-17

Effects of Lamotrigine in Treatment of Depression and Anxiety of Heroin Addicts
LIU Xiaobin,SONG Zhibin.Effects of Lamotrigine in Treatment of Depression and Anxiety of Heroin Addicts[J].Chinese Magazine of Drug Abuse Prevention and Treatment,2006,12(6):326-328.
Authors:LIU Xiaobin  SONG Zhibin
Abstract:Objective:To observe the effects of Lamotrigine in treatment of depression and anxiety of heroin addicts. Methods:72 patients,whose diagnosis is consistent with the criteria of depression and anxiety of heroin addicts (CCMD-2-R),were divided into 2 groups:the Lamotrigine group and the Deanxit group (control). HAMD and HAMA were evaluated before treatment and in the first,third and fifth weekend. Results:The efficacy of Lamotrigine treatment is best in the fifth weekend for the depression and anxiety,which is not better than Deanxit group in first and third weekend (P < 0.05). There is no difference between the two groups in the fifth weekend (P> 0.05). Conclusion:The depression and anxiety of heroin addicts can be relieved by Lamotrigine effectively.
Keywords:Lamotrigine  Heroin addict  Depression and anxiety
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