红细胞比容对急性心肌梗死患者预后的影响

目的 探讨红细胞比容(HCT)与急性心肌梗死(AMI)患者远期病死率之间的相关性.方法 观察分析274例AMI患者的血液及心脏超声指标,并随访患者出院后生存情况,按是否死亡分为死亡组(106例)与非死亡组(168例),通过组间单因素比较、相关性分析以及多因素回归等方法分析各临床指标与病死率之间的相关性.结果 入选的274例患者平均年龄(69.79±7.45)岁,男性200例(73.0%),随访(44.4±10.7)个月,远期病死率为38.7%.2组组间基线资料比较发现NYHA分级、吸烟史、血红蛋白、HCT、平均红细胞体积、肾小球滤过率、射血分数、左室舒张末期内径以及右室内径差异有统计学意义,此9项指标经多因素回归分析结果显示HCT(OR=0.904,95%CI:0.832～0.982,P=0.016)、肾小球率过滤(OR=0.983,95%CI:0.969～0.996,P=0.014)、射血分数(OR=0.932,95%CI:0.887～0.979,P=0.005)以及吸烟史(OR=3.230,95%CI:1.468～7.106,P=0.004)与远期病死率有显著相关性.通过ROC曲线检验HCT的预测效能,计算ROC曲线下面积为0.669(P＜0.001,95%CI:0.603～0.736).结论 HCT可作为AMI患者远期死亡的独立预测因素.

Abstract：

Objective To examine the relationship between hematocrit and risk of long term mortality among patients with acute myocardial infarction. Methods A total of 274 patients with acute myocardial infarction were recruited and divided into two groups by death after long term follow-up, the relationship between hematocrit and mortality was evaluated through the methods of independent t-test,chi-square test and multivariate regression analysis. Results The mean age was 69. 79 ± 7.45 years, with 73. 0% of male. The average of followup was 44. 4± 10. 7 months, with mortality of 38.7% . Comparison of baseline data showed that NYHA classification, smoking history, hemoglobin, hematocrit, mean red cell volume, glomerular filtration rate, ejection fraction,left ventricular diastolic diameter and right ventricular diameter was significantly different between the two groups( Ps ＜ 0. 05), Multivariable logistic analysis showed that hematocrit ,glomerular filtration rate, ejection fraction and smoking history were independently predicted factors, with OR of 0. 904 (95% CI: 0. 832 - 0. 982,P =0. 016) ,0. 983 (95% CI: 0. 969 -0. 996,P =0. 014) ,0. 932 (95% CI: 0. 887 -0. 979,P =0. 005) and 3. 230 (95% CI: 1.468 - 7. 106, P = 0. 004), respectively. The power of hematocrit to predict mortality was examined by ROC curves, the area under the curve was 0. 669(P ＜ 0. 001,95% CI: 0. 603 - 0. 736) Conclusion Hematocrit is a significant independent predictor for long term death among patients with acute myocardial infarction.

Impact of hematocrit on prognosis of patients with acute myocardial infarction

Objective To examine the relationship between hematocrit and risk of long term mortality among patients with acute myocardial infarction. Methods A total of 274 patients with acute myocardial infarction were recruited and divided into two groups by death after long term follow-up, the relationship between hematocrit and mortality was evaluated through the methods of independent t-test,chi-square test and multivariate regression analysis. Results The mean age was 69. 79 ± 7.45 years, with 73. 0% of male. The average of followup was 44. 4± 10. 7 months, with mortality of 38.7% . Comparison of baseline data showed that NYHA classification, smoking history, hemoglobin, hematocrit, mean red cell volume, glomerular filtration rate, ejection fraction,left ventricular diastolic diameter and right ventricular diameter was significantly different between the two groups( Ps ＜ 0. 05), Multivariable logistic analysis showed that hematocrit ,glomerular filtration rate, ejection fraction and smoking history were independently predicted factors, with OR of 0. 904 (95% CI: 0. 832 - 0. 982,P =0. 016) ,0. 983 (95% CI: 0. 969 -0. 996,P =0. 014) ,0. 932 (95% CI: 0. 887 -0. 979,P =0. 005) and 3. 230 (95% CI: 1.468 - 7. 106, P = 0. 004), respectively. The power of hematocrit to predict mortality was examined by ROC curves, the area under the curve was 0. 669(P ＜ 0. 001,95% CI: 0. 603 - 0. 736) Conclusion Hematocrit is a significant independent predictor for long term death among patients with acute myocardial infarction.