| 8-甲氧基补骨脂素的结构简化类似物的合成 |
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| 引用本文： | 裴月湖,孔令义,陈立江,李铣,朱廷儒.8-甲氧基补骨脂素的结构简化类似物的合成[J].中国药物化学杂志,1992(3). |
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| 作者姓名： | 裴月湖 孔令义 陈立江 李铣 朱廷儒 |
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| 作者单位： | 沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，沈阳药学院天然药物研究室 沈阳 110015，沈阳 110015，沈阳 110015，沈阳 110015，沈阳 110015 |
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| 摘 要： | 鉴于花椒毒素有钙离子拮抗作用,根据结构特征,我们对其结构进行了简化,合成了5个化合物。有待药理筛选之后,对其构效关系进行研究。
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| 关 键 词： | 花椒毒素 钙离子拮抗作用 结构简化 类似物合成 |
SYNTHESIS OF COMPOUNDS WITH SIMPLIFIED STRUCTURES OF XANTHOTOXIN |
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| Pei Yuehu Kong Lingyi Chen Lijiang Li Xian Zhu Tingru.SYNTHESIS OF COMPOUNDS WITH SIMPLIFIED STRUCTURES OF XANTHOTOXIN[J].Chinese Journal of Medicinal Chemistry,1992(3). |
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| Authors: | Pei Yuehu Kong Lingyi Chen Lijiang Li Xian Zhu Tingru |
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| Abstract: | Xanthotoxin was first isolated from traditional Chinese medicinal material peucedanum praeruptorum by us. Since xanthotoxin exerts the calcium antagonistic action, we simplified its structure and have synthesized successfully 5 compounds of it according to its structural features. Further structure -activity research will be carried out after the pharmacological experiments. |
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| Keywords: | Xanthotoxin Calcium antagonistic action Structure simplitication |
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