Pyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium falciparum malaria in Lao PDR |
| |
Authors: | Mannoor M Kaiissar Vanisaveth Viengxay Keokhamphavanh Boualy Toma Hiromu Watanabe Hisami Kobayashi Jun Hatabu Toshimitsu Taguchi Nao Hongvangthong Bousy Phetsouvanh Rattanaxay Phompida Samlane Kano Shigeyuki Sato Yoshiya |
| |
Affiliation: | Division of Tropical Parasitology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. kaiissar@med.u-ryukyu.ac.jp |
| |
Abstract: | A 28-day in vivo treatment trial to evaluate the efficacy of pyrimethamine/sulfadoxine (Fansidar, PS) was conducted in 21 Lao patients with uncomplicated Plasmodium falciparum malaria. Sixteen patients (76%) were completely cured with PS without any reappearance of asexual stage parasitemia during the follow-up examination. On the other hand, 5 patients (24%) failed to respond to this trial medication, resulting in recrudescence of asexual stage P. falciparum malaria. PS resistance resulted in higher prevalence of post-treatment gametocytemia, 25% gametocyte carriers among PS sensitive cases versus 75% of the resistant cases. These findings suggest that although the level of PS resistance is still valid for treatment of malaria in the study area of Lao PDR, post-treatment induction of gametocytemia among resistant cases may result an increase in transmission rate of PS resistant falciparum malaria. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|