急性肾炎合并脑病患儿血浆中分子物质含量的变化

目的 探讨急性肾炎及合并高血压脑病患儿血浆中分子物质(MMS)含量的变化及其意义。方法 在患儿治疗前空腹釆静脉血3 ml,同时作MMS,血尿素氮(BUN)和血肌酐(Cr)测定。结果 急性肾炎合并高血压脑病组血浆MMS含量非常显著地高于单纯急性肾炎组和正常对照组(P<0.01),单纯急性肾炎组,正常对照组比较差异无显著性(P>0.05),血浆MMS含量与BUN、Cr浓度无相关性,r值分别为0.21和0.19(P>0.05)。结论 MMS的某些组分有一定神经趋性,有明确的致病作用,急性肾炎合并高血压脑病的发生,可能与血浆中MMS增高有关,清除这些病理性物质,可望达到缓解和治愈的目的。

Change of middle molecule substance (MMS) volume in plasma of children suffered from acute glomenulonephritis along with hypertensive encephalopathy

Objective To study the change of MMS volume of children suffered from acute glomenulonephritis along with hypertensive encephalopathy and its significance. Methods Before treatment, 3ml empty - stomached vein blood were drawn out. MMS, bloodurea nitrogen (BUN) , and creatinine (Cr) were tested. Results The valume of plasma MMS of children with acute glomenulonephritis along with hypertensive encephalopathy was higher than that of pure acute glomeruonephritis group and control group ( P > 0.01) . There was no significant difference between pure acute glomeruonephritis group and normal control group ( P > 0.05) . The volume of plasma MMS was not related to the density of BUN and Cr. R volume was 0.21 and 0. 17 respectively ( P > 0.05) . Conclusion Some components in MMS has certain nerve tendency, and obvious pathogenic function. The development of acute glomenulonephritis along with hypertensive encephalopathy is related with the increase of MMS. Removement of this pathological substance is helpful to cure such diseases.