江西省靖安县农村妇女高危型人乳头状瘤病毒感染的横断面研究

  目的  调查江西省靖安县农村女性子宫颈上皮内高危型人乳头状瘤病毒（high-risk human papillomavirus，hr-HPV）的感染状况。   方法  2012年5月至2012年11月在江西省靖安县地区对35~59岁女性进行人群横断面调查，纳入研究的4 673例受检者中2 491例采用了杂交捕获法（HC-2）方法检测hr-HPV，另外2 182例采用凯普医用核酸分子快速导流杂交基因芯片技术进行hr-HPV检测并分型。   结果   hr-HPV感染率为11.9%，混合感染占41.5%。在进行了分型的2 182例中HPV52型感染率最高（2.8%），其次分别是58、16和39型。hr-HPV感染率在靖安县山区和平原地区之间无差异，年龄分布则有显著性差异（P < 0.001）。   结论  江西省靖安县农村女性hr-HPV感染率与我国其他地区近似，HPV52和58型是该地区优势感染型，hr-HPV感染防治策略应针对不同地域人群的特点有所不同。 

High-risk human papillomavirus infection among rural women of Jing'an County in Jiangxi Province:a cross-sectional study

  Objective   To investigate the prevalence of cervical infection with high-risk human papillomavirus (hr-HPV) among the rural women of Jing-an County in Jiangxi Province.   Methods  A population-based cross-sectional study was conducted among rural women of ages 35 years to 59 years in Jing-an County between May 2012 and November 2012. A total of 4 673 women were enrolled. Hybrid capture2 (hc2) was detected in 2 491 women, whereas HybriMax was detected in 2 182 women to understand the different hr-HPV types.   Results   The overall hr-HPV prevalence was 11.9%. Multiple-type infections accounted for 41.5%. The most commonly seen hr-HPV type was HPV52 (2.8%), followed by HPV58, HPV16, and HPV39. No significant difference was observed in the prevalence of hr-HPV infection between women in the mountainous and the plain areas in Jing-an County. However, the age distribution of HPV infection significantly differed (P < 0.001).   Conclusion   Hr-HPV infection rate in Jing-an County was close to that of other areas in China. HPV52 and HPV58 appeared to be the most prevalent HPV types and should be employed as a basis for HPV prevention in this area.