鼻咽癌放射疗法并中药治疗疗效分析

为了解不同疗法治疗鼻咽癌的效果 ,将 16 3例鼻咽癌病人随机分为 3组 :外照射 +中药 +腔内后装组(EIAIRC) ;外照射 +中药组 (EIC)和单纯外照射组 (SRT)。全部病人行常规放疗。EIAIRC组鼻咽外照射剂量为 5 6～ 6 0Gy,腔内放疗每次 8Gy ,共 2次 ;EIC及SRT组外照射剂量 6 8～72Gy。三组中有颅底骨破坏者小野补量 10Gy。EIAIRC和EIC组于放疗期间配合中药治疗。结果显示 3组病人的 3,5年生存率以及局部复发、远处转移各组间均无统计学差异 ;但放疗伍用中药可减轻鼻咽癌放疗的急性反应。提示早期鼻咽癌外照射配合腔内治疗 ,可减少外照射剂量 (减轻放射损伤 ) ;中药不增加远处转移 ,但可缓和不良反应

Efficacy of radiotherapy combined with traditional Chinese medicine(TCM) in NPC patients

From January 1992 to November 1994, 163 patients with nasopharyngeal carcinoma(NPC) were prospectively randomized into three groups: standard radiotherapy(SRT) group, external irradiation and afterload intracavitary radiation in combination with traditional Chinese medicine(EIAIRC) group, and external irradiation plus traditional Chinese medicine(EIC) group. All patients were treated with usual radiotherapy. The nasopharynx’s radiation dose was 50～60?Gy, intracavitary irradiation 16?Gy/2 times(The distance from radiation source to spot of reference was 14?mm away). The radiation dose in EIC and SRT group was 68～72?Gy, respectively. The results were as follows: ① There were no statistical difference among the three groups in 3year or 5year survival rate and no local relapse or distant metastasis. ② The TCM alleviated the acute radiation reaction and damage effects. It indicates that the therapy might decrease radiation dose and the TCM does not induce NPC distant metastasis.