| 小牛血清培养基中增补蛋氨酸促进大鼠胚胎神经管闭合 |
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| 引用本文： | 朱慧萍,李竹,王秋枫,赵树芬,张秀池. 小牛血清培养基中增补蛋氨酸促进大鼠胚胎神经管闭合[J]. 北京大学学报(医学版), 1996, 0(5) |
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| 作者姓名： | 朱慧萍 李竹 王秋枫 赵树芬 张秀池 |
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| 作者单位： | 北京医科大学中国妇婴保健中心 |
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| 摘 要： | 目的：研究必需氨基酸蛋氨酸对大鼠胚胎神经管发育的影响。方法：大鼠体外全胚胎培养。结果：９．５ｄ大鼠胚胎在小牛血清中培养４８ｈ，观察到其发育明显落后于正常大鼠血清组，神经管严重未闭，添加了蛋氨酸的小牛血清（终浓度为２５．４４ｍｇ／Ｌ）中，胚胎发育仍现迟缓，但神经管闭合。结论：小牛血清中增补蛋氨酸有促进大鼠胚胎神经管闭合的作用。
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| 关 键 词： | 蛋氨酸／药理学；神经管缺损／预防和控制；胚胎／生长和发育 |
METHIPONINE SUPPLEMENTATION PROMOTES THE NEURAL TUBE CLOSURE OF WHOLE RAT EMBRYOS CULTURED IN COW SERUM |
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| ZHU Huiping,LI Zhu, WANG Qiufeng,ZHAO Shufen , ZHANG Xiuchi. METHIPONINE SUPPLEMENTATION PROMOTES THE NEURAL TUBE CLOSURE OF WHOLE RAT EMBRYOS CULTURED IN COW SERUM[J]. Journal of Peking University. Health sciences, 1996, 0(5) |
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| Authors: | ZHU Huiping LI Zhu WANG Qiufeng ZHAO Shufen ZHANG Xiuchi |
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| Abstract: | Objective:To study the effect of methionine on neural tube closure of rat embryos. Methods:whole embryo culture. Results: embryos cultured in cow serum have open neural tubes after 48 h while those cultured with methionine supplementation have normal neural tube closure. Conclusion:Methion-ine supplementation to cow serum promotes the neural tube closure of cultured rat embryos. |
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| Keywords: | Methionine/pharmacal:Neural tube defects/prev Embryo/growth |
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