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| 异位骨化预防性放疗对骨折愈合影响的实验研究 | |
| 引用本文： | 鲍 琨 史思峰 苟三怀 张修龙 郭尚春. 异位骨化预防性放疗对骨折愈合影响的实验研究[J]. 生物骨科材料与临床研究, 2010, 7(2): 5-9. DOI: 10.3969/j.issn.1672-5972.2010.02.002 |
| 作者姓名： | 鲍 琨 史思峰 苟三怀 张修龙 郭尚春 |
| 作者单位： | 1. 第二军医大学附属长征医院骨科,上海,200003 2. 上海交通大学医学院,上海,200233 3. 上海交通大学附属第六人民医院,上海,200233 |
| 摘 要： | 目的探索骨折后48h给予单次放疗预防异位骨化的同时对骨折愈合造成的影响,并将其用于创伤骨折初期预防异位骨化的可能性。方法取成年SD大鼠50只,随机分成5组,制成双侧股骨骨折模型,实验侧骨折后48h予放疗,对侧为对照侧。分别于骨折后2周、4周、8周、12周、16周取双侧股骨,进行放射学,组织学和生物力学评估骨折愈合情况。实验还采取实验侧伤口旁皮毛和部分股四头肌组织作组织学观察。结果骨折后4周时实验侧骨痂厚度明显小于对照侧(0.05),其余各组双侧无显著性差异;骨组织切片观察发现骨折2周组中实验侧的股骨愈合的组织学评分显著低于对照侧(0.05),其余各组双侧无显著性差异;生物力学测试,4周组大鼠的实验侧股骨最大弯曲载荷显著低于对照侧(0.05),其余各组双侧无显著性差异。结论用于预防异位骨化的单次小剂量放疗的确在早期抑制了骨折修复,骨折都是会逐步愈合,只是愈合的时间相对延长。这种放疗对皮肤伤口愈合,毛发生长,骨周围软组织无明显损害。临床应用尚需进一步论证。 |
| 关 键 词： | 放疗 骨折愈合 异位骨化 |
The effect of heterotopic osteogenesis preventive radiation on fracture healing: An animal model study |
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| Bao Kun Shi Shifeng Zhang Xiulong et al.. The effect of heterotopic osteogenesis preventive radiation on fracture healing: An animal model study[J]. Orthopaedic Biomechanics Materials and Clinical Study, 2010, 7(2): 5-9. DOI: 10.3969/j.issn.1672-5972.2010.02.002 | |
| Authors: | Bao Kun Shi Shifeng Zhang Xiulong et al. |
| Affiliation: | Bao Kun Shi Shifeng Zhang Xiulong et al.1.Department of orthopedics,Changxheng Hospital affiliated to the Second Military Medical University,Shanghai,200003 2.Shanghai Jiao Tong University Medical College,shanghai2000233 |
| Abstract: | Objective To investigate the effect of a single heterotopic osteogenesis preventive radiation administered 48h after fracture on its healing. and to assess the possibility of its application in the early management of susceptible fractures. Methods 50 adult SD rats were randomly devided into 5 groups which were to sacrifice in 2, 4, 8, 12, 16 weeks repec- tively. Both their femurs were osteotomized and fixed with intramedullar pins, one side was irradiated 48h later, the other was reserved as control. In du... |
| Keywords: | Irradiation Fracture healing Heterotopic osteogenesis |
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