汉族急性心肌梗死患者DNA酶I基因多态性与血脂、血糖的关系研究

目的:探讨汉族急性心肌梗死患者DNaseI基因A2317G位点的基因型及与血脂、血糖的关系。方法:应用PcR-LoR法分析汉族急性心肌梗死患者DNaseI基因多态性,计算各基因型分布频率,不同基因型与空腹血糖、血脂的相关性。采用sAs软件进行统计分析。结果:汉族AMI患者中DNA酶摹基因A2317G位点基因型和等位基因频率分布符合Hardy-weinberg平衡定律,A2317G位点等位基因频率分别为0.52、0.48,不同基因型的血酯、血糖水平差异无统计学意义(P>0.05)。结论:AMI患者中A2317G位点等位基因频率与与亚洲人群中的蒙古人、日本人相似,而与韩国人、土耳其人、纳米比亚人和德国人明显不同,DNaseI基因多态性具有显著的种族异质性。

Correlation Analysis Between DNA Enzymes I Genetic Polymorphism and Blood Fat and Blood Sugar in the Crowd of Han Nationality with Acute Myocardial infarction

Objective To explore the relationship DNA enzymes I A2317G gene locus genotype and the blood fat,sugar levels of the blood in the crowd of the han with acute myocardial infarction.Methods The genotype distribution and frequency of DNA enzymes! gene polymorphism with PCR-LDR analysis in Han nationality with acute myocardial infarction,analysis correlation between different genotypes and blood glucose,blood fat.Using SAS software in statistical analysis.Results Han nationality AMI crowd enzyme gene A2317G sites I DNA genotype and allele frequencydistribution meet Hardy-Weinberg balance law,A2317G site allele frequency were 0.52,0.48,different genotypes of blood,blood sugar level differences were not statistically significant(P>0.05).Conclusion Allele frequency of A2317G sites in AMI crowd was similar with Asia the crowd Mongolia,Japanese,it was markedly different with’ Korean,Turkey,namibia and Germany,DNase I gene polymorphism had significant ethnic heterogeneity.