Rectal absorption of metronidazol from polyethylene glycol suppositories |
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Authors: | H. Vromans F. Moolenaar J. Visser D. K. F. Meijer |
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Affiliation: | (1) Department of Pharmacology and Pharmacotherapeutics, Subfaculty of Pharmacy, State University of Groningen, Ant. Deusinglaan 2, 9713 AW Groningen, The Netherlands |
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Abstract: | The rectal absorption of metronidazol from an aqueous suspension, a fatty suppository and three different polyethylene glycol suppositories was studied in healthy volunteers and compared with absorption from an oral solution. Rectal absorption was found to be rather slow for all suppositories. Of all rectal dosage forms, the polyethylene glycol suppositories gave the highest peak plasma levels and the highest relative bioavailability. Compared with oral administration, a relative bioavailability of 80% could be obtained. |
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