急性心脑血管病与颈动脉IMT及血清hs-CRP的相关性研究

目的 探讨颈动脉内膜-中层厚度(IMT)及血清超敏C反应蛋白(hs-CRP)与急性心脑血管病的相关性.方法 利用彩色多普勒超声诊断仪测定颈动脉IMT,检测血清hs-CRP水平,并分析二者相关性.结果 患病组颈动脉IMT、粥样硬化斑块检出率均高于健康对照组,差异有统计学意义(P＜0.01).入院时急性期患者血清hs-CRP水平为(7.98士2.31) mg/L,显著高于出院时[(7.05±2.05) mg/L],差异有统计学意义(P＜0.05).健康对照组血清hs-CRP水平为(1.15±1.02)mg/L,显著低于入院及出院时急性期患者血清hs-CRP的水平,差异有统计学意义(P＜0.01).入院时急性期患者血清hsCRP水平为(7.98±2.31)mg/L,显著高于慢性期患者[(1.21±0.95)mg/L],差异有统计学意义(P＜0.01).结论 斑块的不稳定性是导致急性心脑血管病的决定因素.血清hs-CRP水平越高,斑块不稳定性越高,发生急性心脑血管病的风险越高.颈动脉IMT及血清hs-CRP与急性心脑血管病发病密切相关.

Correlation research between acute cardiocerebrovascular diseases with carotid IMT and serum hs-CRP

Objective To investigate the correlation between acute cardiocerebrovascular diseases with the carotid intima-media thick ness （1MT） and serum high sensitivity C-reactive protein （hs-CRP）. Methods The color Doppler ultrasound instrument was adopted to determine carotid IMT and serum hs-CRP levels and to analyze their con＇elation. Results The detection rate of carotid IMT and atherosclerotic plaque in the patients group was higher than that in the healthy control group （P〈0.01）. The serum hs-CRP levels at the acute stage on admission was （7.98＋2.31 ）mg/L and significantly higher than （7.05±2.05）mg/1, on discharge with statistical difference between them （P〈0.05）. The hs-CRP level in the healthy control group was （1.15±1.02）mg/L and significantly lower than that at the acute stage on admission and discharge （P〈0.01）. The serum CRP levels at the acute stage was（7.98±2.31 ）mg/L and significantly higher than（ 1.21±0.95）mg/L at the chronic stage with statistical difference （P〈0.01）. Conclusion The plaque instability is the determinant leading to acute cardiocerebrovascular diseases. The higher serum hs-CRP level, the higher the plaque instability and the higher the risk of acute cardiocerebrovascular disease occurrence. Carotid IMT and serum hs-CRP are closely correlated with the occurrence of acute cardiocerebrovascular diseases.