| 氧氟沙星控释人工骨的制备及释药机理的探讨 |
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| 引用本文： | 景利 曾仁杰. 氧氟沙星控释人工骨的制备及释药机理的探讨[J]. 华西药学杂志, 1996, 11(3): 137-139 |
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| 作者姓名： | 景利 曾仁杰 |
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| 作者单位： | 成都军区总医院 |
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| 摘 要： | 以蜂蜡和乙基纤维素为阻滞剂，包裹羟基磷灰石生物陶瓷人工骨（ＰＨＡ），内载药物氧氟沙星（ＯＦＬＸ），制成氧氟沙星控释人工骨（ＯＦＬＸ－ＰＨＡ）。对ＯＦＬＸ－ＰＨＡ进行了体外释药量实验。探讨ＰＨＡ包裹阻滞剂后，药物ＯＦＬＸ的释放规律，以及影响ＯＦＬＸ－ＰＨＡ释药速率的因素。
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| 关 键 词： | 羟基磷灰石 陶瓷人工骨 氧氟沙星 体外释药 |
PREPARATIN OF RELEALING CONTROLLED OFLOXACIN POROUS HYOLROXYAPATITE AND RELEASING MECHANISM |
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| Jing Li,Zheng Renjie,Liu Mingrong,Sun Weizhang,Qing Lei,Liu Fengfeng. PREPARATIN OF RELEALING CONTROLLED OFLOXACIN POROUS HYOLROXYAPATITE AND RELEASING MECHANISM[J]. West China Journal of Pharmaceutical Sciences, 1996, 11(3): 137-139 |
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| Authors: | Jing Li Zheng Renjie Liu Mingrong Sun Weizhang Qing Lei Liu Fengfeng |
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| Affiliation: | Phamacy Department of Chengdu Central Hospital of PLA Chengdu 610083 |
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| Abstract: | Releasing controlled ofloxacin porous hydroxyapatite(OFLX-PHA) was prepared with wax and efhylcellulose as aretardant.porous hydroxylapatite asa carrier.Experiment of drug-releasing in vitro was made.The drug-releasing mechanism and its affecting-factor of OFLX-PHA was investigated. |
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| Keywords: | Porous hydroxylapatite Ofloxacin Wax Ethylcellulose Drug-releasing in vitro |
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