| 黑色素生物合成抑制剂MA—18化学结构和生物学活性的研究 |
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| 引用本文： | 郑榕 林永珠. 黑色素生物合成抑制剂MA—18化学结构和生物学活性的研究[J]. 中国抗生素杂志, 1997, 22(1): 8-11,7 |
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| 作者姓名： | 郑榕 林永珠 |
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| 作者单位： | 国家医药管理局福建省微生物研究所!福州，350007，国家医药管理局福建省微生物研究所!福州，350007，国家医药管理局福建省微生物研究所!福州，350007，国家医药管理局福建省微生物研究所!福州，350007，国家医药管理局福建省微生物研究所!福州，350007，国家医药管理局福建省微生物研究 |
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| 摘 要： | 从棘孢小单孢福建亚种的发酵液中提取的黑色素生物合成抑制剂ＭＡ－１８，经提取，纯化和理化性质鉴别，根据元素分析、ＥＩ－ＭＳ和＾１３Ｃ－ＮＭＲ的结果，确定其分子式为Ｃ７Ｈ７ＮＯ２，分子量１３７。分析１Ｈ－ＮＭＲ和＾１３Ｃ－ＮＭＲ主要信号的归属，推测ＭＡ－１８为苯的衍生物。
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| 关 键 词： | 黑色素 生物合成抑制剂 MA－18 |
MA-18,a melanin biosynthesis inhibitor-production,isolation, physico-chemical properties,structure and biological activity |
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| Zheng Rong, Lin Yongzhu, Chen Lie, Xie Yang,Chen Hang and Cheng Yuanrong. MA-18,a melanin biosynthesis inhibitor-production,isolation, physico-chemical properties,structure and biological activity[J]. Chinese Journal of Antibiotics, 1997, 22(1): 8-11,7 |
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| Authors: | Zheng Rong Lin Yongzhu Chen Lie Xie Yang Chen Hang Cheng Yuanrong |
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| Abstract: | MA-18, a melanin biosynthesis inhibitor, was isolated from the fermenta-tion broth of Micromonospora echinospora subsp. fujianensis No. 80-A18. Its molecularformular, C7H7NO2(MW 137), was determined by elemental analysis, EI-MS and 13C-NMRspectrum, MA-18 was considered as a benzene derivative on the basis of its data of H-NMRand 13C-NMR.The melanin biosynthesis inhibitor, MA-18, inhibited the production of hydrogensulifide by Streptoverticillium melosporum 8o-A16 and inhibited the activity of tyrosinase byStreptomyces glaucus 93-5 and by mushroom respectively, and also showed weaklyantibacterial activity against Staphylococcus aureus. |
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| Keywords: | Melanin biosynthesis inhibitor MA-18 Micromonospora echinospora subsp fujianensis |
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